Therapeutic potential of plant polyphenols in acute pancreatitis
Department
Internal Medicine
Document Type
Article
Publication Title
Inflammopharmacology
Abstract
Acute pancreatitis is a potentially life-threatening inflammatory disorder of the exocrine pancreas characterized by early activation of pancreatic enzymes followed by macrophage-driven inflammation, and pancreatic acinar cell death. The most common causes are gallstones and excessive alcohol consumption. Inflammation and oxidative stress play critical roles in its pathogenesis. Despite increasing incidence, currently, no specific drug therapy is available to treat or prevent acute pancreatitis, in particular severe acute pancreatitis. New therapeutic agents are very much needed. Plant polyphenols have attracted extensive attention in the field of acute pancreatitis due to their diverse pharmacological properties. In this review, we discuss the potential of plant polyphenols in inhibiting the occurrence and development of acute pancreatitis via modulation of inflammation, oxidative stress, calcium overload, autophagy, and apoptosis, based on the currently available in vitro, in vivo animal and very few clinical human studies. We also outline the opportunities and challenges in the clinical translation of plant polyphenols for the treatment of the disease. We concluded that plant polyphenols have a potential therapeutic effect in the management and treatment of acute pancreatitis. Knowledge gained from this review will hopefully inspire new research ideas and directions for the development and application of plant polyphenols for treating this disease.
First Page
785
Last Page
798
DOI
10.1007/s10787-024-01584-y
Volume
33
Issue
2
Publication Date
2-1-2025
Medical Subject Headings
Polyphenols; Pancreatitis; Humans; Animals; Oxidative Stress; Acute Disease; Inflammation; Apoptosis; Autophagy; Plant Extracts
PubMed ID
39497005
Recommended Citation
Niu, C., Zhang, J., & Okolo, P. I. (2025). Therapeutic potential of plant polyphenols in acute pancreatitis. Inflammopharmacology, 33 (2), 785-798. https://doi.org/10.1007/s10787-024-01584-y
