Association of Medication Adherence and Health Status in Heart Failure With Reduced Ejection Fraction: Insights From the CHAMP-HF Registry

Department

Cardiology

Document Type

Article

Publication Title

Circulation. Cardiovascular Quality and Outcomes

Abstract

Background: The foundation for managing heart failure with reduced ejection fraction (HFrEF) is adherence to guideline-directed medical therapy. Finding an association between medication adherence and patients' health status (their symptoms, function, and quality of life) can be used to underscore its importance to patients.

Methods: The association of self-reported medication adherence in US outpatients with HFrEF enrolled in the Change the Management of Patients with Heart Failure registry from 2015 to 2017 was compared with their health status at baseline and 12 months later. A secondary analysis of changes in adherence between baseline and 6 months with 6-month health status was also performed. Medication adherence was assessed with the self-reported 4-item Morisky-Green-Levine Medication Adherence Scale, with scores ≥1 classified as nonadherent. The primary health status outcome was the disease-specific 12-item Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS; range, 0-100; higher is better). Robust linear regression models adjusted for confounders were used.

Results: After excluding those who died (n=316) or did not provide 12-month KCCQ (n=1285), 3495 outpatients with HFrEF were included, of whom 1108 (31.7%) reported being nonadherent. Nonadherent participants were younger, had significantly worse baseline health status (-5.83-point difference; P< 0.001), and showed less improvement at 12 months (-1.7-point difference in mean change; P=0.017) than adherent participants. Among nonadherent patients at baseline, those whose adherence improved trended toward greater 6-month health status improvements than those remaining nonadherent (fully adjusted difference of 2.52 points; P=0.054).

Conclusions: In HFrEF, medication nonadherence was associated with worse health status and less improvement over the following year. Improvements in adherence were associated with better health status than remaining nonadherent, underscoring the importance of supporting adherence with guideline-directed medical therapy in patients with HFrEF.

First Page

e010211

DOI

10.1161/CIRCOUTCOMES.123.010211

Volume

17

Issue

9

Publication Date

9-1-2024

Medical Subject Headings

Humans; Heart Failure (drug therapy, physiopathology, diagnosis, mortality); Medication Adherence; Male; Female; Stroke Volume; Registries; Aged; Middle Aged; Quality of Life; Time Factors; United States; Health Status; Treatment Outcome; Ventricular Function, Left (drug effects); Cardiovascular Agents (therapeutic use, adverse effects); Self Report; Aged, 80 and over

PubMed ID

39045701

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