Cardiovascular complications during delivery hospitalizations in patients with nonalcoholic fatty liver disease in pregnancy

Department

Internal Medicine

Additional Department

Gastroenterology

Document Type

Article

Publication Title

European Journal of Gastroenterology & Hepatology

Abstract

OBJECTIVE: While the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and long-term cardiovascular risks has been studied, the impact of MASLD on cardiovascular events during delivery hospitalizations remains relatively unexplored. This study aims to examine the prevalence of cardiovascular diseases (CVDs) and cardiac arrhythmias in pregnant patients with MASLD and identify potential risk factors.

METHODS: A retrospective analysis of hospital discharge records from the National Inpatient Sample database between 2009 and 2019 was conducted to assess maternal cardiovascular outcomes. Multivariable logistic regression models were employed, and adjusted odds ratios (AOR) were calculated to evaluate the association between MASLD and cardiovascular outcomes during pregnancy.

RESULTS: The study sample included 17 593 pregnancies with MASLD and 41 171 211 pregnancies without this condition. Women with MASLD exhibited an increased risk of congestive heart failure [AOR 3.45, 95% confidence interval (CI) 1.04-11.43], cardiac arrhythmia (AOR 2.60, 95% CI 1.94-3.49), and gestational hypertensive complications (AOR 3.30, 95% CI 2.93-3.72). Pregnancies with MASLD were also associated with a higher rate of pulmonary edema (AOR 3.30, 95% CI 1.60-6.81).

CONCLUSION: MASLD is an independent risk factor for cardiovascular complications during delivery hospitalizations, emphasizing the necessity for prepregnancy screening and targeted prevention strategies to manage CVD risks in expectant patients with MASLD.

First Page

1141

Last Page

1148

DOI

10.1097/MEG.0000000000002802

Volume

36

Issue

9

Publication Date

9-1-2024

Medical Subject Headings

Humans; Pregnancy; Female; Adult; Retrospective Studies; Non-alcoholic Fatty Liver Disease (epidemiology, complications); Hospitalization (statistics & numerical data); Risk Factors; Pregnancy Complications (epidemiology); Arrhythmias, Cardiac (epidemiology, etiology); Prevalence; Cardiovascular Diseases (epidemiology, etiology); Delivery, Obstetric (statistics & numerical data); Pulmonary Edema (epidemiology, etiology); Hypertension, Pregnancy-Induced (epidemiology); United States (epidemiology); Young Adult; Heart Failure (epidemiology, etiology); Pregnancy Complications, Cardiovascular (epidemiology)

PubMed ID

38874917

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