Basic Principles and Role of Endoscopic Ultrasound in Diagnosis and Differentiation of Pancreatic Cancer from Other Pancreatic Lesions: A Comprehensive Review of Endoscopic Ultrasound for Pancreatic Cancer

Authors

Dushyant Singh Dahiya, Division of Gastroenterology, Hepatology and Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, USA.
Yash R. Shah, Department of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, USA.
Hassam Ali, Division of Gastroenterology, Hepatology & Nutrition, East Carolina University/Brody School of Medicine, Greenville, NC 27858, USA.
Saurabh Chandan, Division of Gastroenterology and Hepatology, Creighton University School of Medicine, Omaha, NE 68178, USA.
Manesh Kumar Gangwani, Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Andrew Canakis, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Daryl Ramai, Division of Gastroenterology and Hepatology, The University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Umar Hayat, Department of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA 18711, USA.
Bhanu Siva Pinnam, Department of Internal Medicine, John H. Stroger Hospital of Cook County, Chicago, IL 60612, USA.
Amna Iqbal, Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
Sheza Malik, Rochester Regional HealthFollow
Sahib Singh, Department of Internal Medicine, Sinai Hospital, Baltimore, MD 21215, USA.
Fouad Jaber, Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, USA.
Saqr Alsakarneh, Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO 64110, USA.
Islam Mohamed, Division of Hepatology, University of Missouri School of Medicine, Columbia, MO 64108, USA.
Meer Akbar Ali, Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Mohammad Al-Haddad, Division of Gastroenterology and Hepatology, University of Jordan, 11942 Amman, Jordan.
Sumant Inamdar, Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Department

Internal Medicine

Document Type

Article

Publication Title

Journal of Clinical Medicine

Abstract

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Pancreatic lesions consist of both neoplastic and non-neoplastic lesions and often pose a diagnostic and therapeutic challenge due to similar clinical and radiological features. In recent years, pancreatic lesions have been discovered more frequently as incidental findings due to the increased utilization and widespread availability of abdominal cross-sectional imaging. Therefore, it becomes imperative to establish an early and appropriate diagnosis with meticulous differentiation in an attempt to balance unnecessary treatment of benign pancreatic lesions and missing the opportunity for early intervention in malignant lesions. Endoscopic ultrasound (EUS) has become an important diagnostic modality for the identification and risk stratification of pancreatic lesions due to its ability to provide detailed imaging and acquisition of tissue samples for analysis with the help of fine-needle aspiration/biopsy. The recent development of EUS-based technology, including contrast-enhanced endoscopic ultrasound, real-time elastography-endoscopic ultrasound, miniature probe ultrasound, confocal laser endomicroscopy, and the application of artificial intelligence has significantly augmented the diagnostic accuracy of EUS as it enables better evaluation of the number, location, dimension, wall thickness, and contents of these lesions. This article provides a comprehensive overview of the role of the different types of EUS available for the diagnosis and differentiation of pancreatic cancer from other pancreatic lesions while discussing their key strengths and important limitations.

First Page

2599

DOI

10.3390/jcm13092599

Volume

13

Issue

9

Publication Date

4-28-2024

PubMed ID

38731128

Recommended Citation

Dahiya, D. S., Shah, Y. R., Ali, H., Chandan, S., Gangwani, M. K., Canakis, A., Ramai, D., Hayat, U., Pinnam, B. S., Iqbal, A., Malik, S., Singh, S., Jaber, F., Alsakarneh, S., Mohamed, I., Ali, M. A., Al-Haddad, M., & Inamdar, S. (2024). Basic Principles and Role of Endoscopic Ultrasound in Diagnosis and Differentiation of Pancreatic Cancer from Other Pancreatic Lesions: A Comprehensive Review of Endoscopic Ultrasound for Pancreatic Cancer. Journal of Clinical Medicine, 13 (9), 2599. https://doi.org/10.3390/jcm13092599