Adipokines and incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis

Authors

Eric K. Broni, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oluseye Ogunmoroti, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Renato Quispe, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ty Sweeney, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bhavya Varma, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oluwaseun E. Fashanu, Rochester Regional HealthFollow
Pamela L. Lutsey, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Matthew Allison, Department of Family Medicine, University of California San Diego, La Jolla, California, USA.
Moyses Szklo, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Chiadi E. Ndumele, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Erin D. Michos, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Department

Cardiology

Document Type

Article

Publication Title

Journal of Thrombosis and Haemostasis

Abstract

Background: Obesity leads to adipocyte hypertrophy and adipokine dysregulation and is an independent risk factor for venous thromboembolism (VTE). However, the association between adipokines and VTE is not well established.

Objectives: To examine whether adipokines are associated with increased risk of incident VTE.

Methods: We studied 1888 participants of the Multi-Ethnic Study of Atherosclerosis cohort who were initially free of VTE and had adipokine (adiponectin, leptin, and resistin) levels measured at either examination 2 or 3 (2002-2004 or 2004-2005, respectively). During follow-ups, VTE was ascertained through hospitalization records and death certificates by using ICD-9 and 10 codes. We used multivariable Cox proportional hazards regression to assess the association between 1 standard deviation (SD) log-transformed increments in adipokines and incident VTE.

Results: The mean ± SD age was 64.7 ± 9.6 years, and 49.8% of participants were women. Medians (interquartile range) of adiponectin, leptin, and resistin were 17.3 (11.8-26.2) mcg/mL, 13.5 (5.6-28.2) ng/mL, and 15.0 (11.9-19.0) ng/mL, respectively. There were 78 incident cases of VTE after a median of 9.7 (5.0-12.4) years of follow-up. After adjusting for sociodemographics, smoking, and physical activity, the hazard ratios (95% CIs) per 1 SD increment of adiponectin, leptin, and resistin were 1.14 (0.90-1.44), 1.29 (1.00-1.66), and 1.38 (1.09-1.74), respectively. The association for resistin persisted after further adjustments for body mass index and computed tomography-derived total visceral adipose tissue area.

Conclusion: Higher resistin levels were independently associated with greater risk of incident VTE. Larger prospective cohort studies are warranted to confirm this association.

First Page

303

Last Page

310

DOI

10.1016/j.jtha.2022.11.012

Volume

21

Issue

2

Publication Date

2-1-2023

PubMed ID

36700499

Recommended Citation

Broni, E. K., Ogunmoroti, O., Quispe, R., Sweeney, T., Varma, B., Fashanu, O. E., Lutsey, P. L., Allison, M., Szklo, M., Ndumele, C. E., & Michos, E. D. (2023). Adipokines and incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis. Journal of Thrombosis and Haemostasis, 21 (2), 303-310. https://doi.org/10.1016/j.jtha.2022.11.012