Decreased TNF family receptor expression on B-cells is associated with reduced humoral responses to Streptococcus pneumoniae infections in young children

Department

Research

Document Type

Article

Publication Title

Cellular Immunology

Abstract

An underdeveloped or impaired immune response in young children is associated with increased susceptibility to Streptococcus pneumonia (Spn) infections. We determined serum antibody titers against 3 Spn vaccine candidate proteins and vaccine serotype polysaccharide antigens in a group of Spn infection prone 9-18months old and found lower IgG antibody titers to all tested antigens compared to age-matched non-infection-prone children. We also found the children had significantly reduced percentages of total memory B-cells, switched memory B-cells and plasma cells. We sought a mechanistic explanation for that result by examination of TNF family receptors (TNFRs) TACI, BCMA, and BAFFR receptor expression on B-cells and found significantly lower BAFFR and TACI expression; significantly lower proliferation of B-cells stimulated with exogenous BAFF; and diminished expression of co-stimulatory receptors B7-1 and B7-2 among infection prone vs. non-prone children. We conclude that lower expression of TNFRs, lower proliferation of B-cells in response to BAFF and lower expression of B7-1 and B7-2 by B-cells may contribute to reduced antibody responses to Spn and consequent infection proneness in young children.

First Page

11

Last Page

19

DOI

10.1016/j.cellimm.2017.07.004

Volume

320

Publication Date

10-1-2017

Medical Subject Headings

Antibodies, Bacterial (blood); B-Cell Activation Factor Receptor (metabolism); B-Lymphocytes (immunology, microbiology); B7-1 Antigen (metabolism); B7-2 Antigen (metabolism); Cell Proliferation; Cells, Cultured; Disease Susceptibility; Female; Humans; Immunoglobulin G (blood); Immunologic Memory; Infant; Lymphocyte Activation; Male; Otitis (immunology); Pneumococcal Infections (immunology); Pneumococcal Vaccines (immunology); Streptococcus pneumoniae (immunology); Transmembrane Activator and CAML Interactor Protein (metabolism); Vaccination

PubMed ID

28947093

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