Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin
Department
Research
Document Type
Article
Publication Title
Human Vaccines & Immunotherapeutics
Abstract
Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade. We compared CD4 T cell and B cell responses induced by genetically detoxified pertussis toxin (PTg) and chemically detoxified pertussis toxin (PTc) using naive human neonatal cells. Responses to novel adjuvants were also assessed. PTg induced significant antigen-specific CD4 T cell activation and IL17 secretion than PTc. TLR agonist combinations improved PTg induced T cell-CD69 expression and IL17 secretion.
First Page
1167
Last Page
1170
DOI
10.1080/21645515.2019.1565270
Volume
15
Issue
5
Publication Date
1-1-2019
Medical Subject Headings
Antigens, CD (genetics); Antigens, Differentiation, T-Lymphocyte (genetics); CD4-Positive T-Lymphocytes (immunology); Cells, Cultured; Fetal Blood (cytology); Humans; Inactivation, Metabolic; Infant, Newborn; Interleukin-17 (immunology); Lectins, C-Type (genetics); Leukocytes, Mononuclear (immunology); Lymphocyte Activation; Pertussis Toxin (chemistry, genetics, immunology); Pertussis Vaccine (immunology)
PubMed ID
30689515
Recommended Citation
Surendran, N., & Pichichero, M. (2019). Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin. Human Vaccines & Immunotherapeutics, 15 (5), 1167-1170. https://doi.org/10.1080/21645515.2019.1565270