Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer

Authors

Jasmine Shrestha, Nepal Medical College, Kathmandu, NPL
Asis Shrestha, Rochester Regional HealthFollow
Pratul Karki, Bassett Medical Center, Cooperstown
Ajay Dhakal, University of Rochester Medical Center, Rochester

Department

Internal Medicine

Document Type

Article

Publication Title

Cureus

Abstract

Leptomeningeal disease (LMD) occurs in less than 5% of breast cancer patients. Rarely, patients present with LMD at diagnosis. We report a case of a 59-year-old female who presented with lower back pain, radicular neuropathy with lower extremity weakness, and was found to have diffuse LMD. Workup was initiated to evaluate the etiology of LMD and later involved iliac bone biopsy showed metastatic adenocarcinoma consistent with breast carcinoma. Patient received radiation therapy followed by abemaciclib with letrozole and responded well with the treatment.

First Page

e19666

DOI

10.7759/cureus.19666

Volume

13

Issue

11

Publication Date

11-17-2021

PubMed ID

34956772

Recommended Citation

Shrestha, J., Shrestha, A., Karki, P., & Dhakal, A. (2021). Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer. Cureus, 13 (11), e19666. https://doi.org/10.7759/cureus.19666