Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management
Department
Allergy and Immunology
Document Type
Article
Publication Title
Current Allergy and Asthma Reports
Abstract
PURPOSE OF STUDY: Immune-mediated adverse drug reactions occur commonly in clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated hypersensitivity, and severe cutaneous adverse drug reactions (SCAR). SCARs represent an uncommon but potentially life-threatening form of delayed T cell-mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis (AGEP) to drug reaction with eosinophilia with systemic symptoms (DRESS), to the most severe form of illness, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
RECENT FINDINGS: There is emerging literature on the efficacy of cyclosporine in decreasing mortality in SJS/TEN. The purpose of our review is to discuss the typical presentations of these conditions, with a special focus on identifying the culprit medication. We review risk factors for developing SCAR, including HLA alleles strongly associated with drug hypersensitivity. We conclude by discussing current strategies for the management of these conditions.
First Page
26
DOI
10.1007/s11882-018-0778-6
Volume
18
Issue
4
Publication Date
3-24-2018
Medical Subject Headings
Drug Eruptions; Humans; Risk Factors
PubMed ID
29574562
Recommended Citation
Mustafa, S. S., Ostrov, D., & Yerly, D. (2018). Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management. Current Allergy and Asthma Reports, 18 (4), 26. https://doi.org/10.1007/s11882-018-0778-6