Spontaneous Tumour Lysis Syndrome in Multiple Myeloma with Loss of 17p13.1, t(4;14) and Monosomy 13
Department
Internal Medicine
Document Type
Article
Publication Title
BMJ Case Reports
Abstract
Tumour lysis syndrome (TLS) is a constellation of metabolic derangements caused by lysis of tumour cells. It is an oncological emergency that is considered a rare occurrence in multiple myeloma (MM) and usually occurs after patients have been treated with chemotherapy. We describe a very rare case of TLS occurring before the official diagnosis or treatment of MM. We report infrequent karyotype abnormalities, including loss of 17p13.1 (TP53 mutation), t(4;14) (FGFR3/IGH fusion) and monosomy 13, that have not been explicitly described in association with spontaneous tumour lysis syndrome (STLS) in MM. This case adds to the sparse literature available on STLS in MM, which is a life-threatening situation requiring urgent medical intervention.
First Page
e234122
DOI
10.1136/bcr-2019-234122
Volume
14
Issue
2
Publication Date
2-5-2021
PubMed ID
33547114
Recommended Citation
Tbakhi, B., Hanna, S., Samhouri, Y., & Lingutla, D. (2021). Spontaneous Tumour Lysis Syndrome in Multiple Myeloma with Loss of 17p13.1, t(4;14) and Monosomy 13. BMJ Case Reports, 14 (2), e234122. https://doi.org/10.1136/bcr-2019-234122