Rare Coagulation Factor Deficiencies (Factors VII, X, V, and II)

Department

Oncology and Hematology

Document Type

Article

Publication Title

Hematology/oncology clinics of North America

Abstract

Although rare clotting factor deficiencies primarily referred to as rare bleeding disorders (RBD), including factors II, V, VII, and X, make up ∼5% of all inherited bleeding disorders worldwide, each of these clotting factors play a critical role in the coagulation cascade. Incomplete bleeding evaluation or misinterpretation of laboratory studies can result in delayed diagnoses that ultimately affect patient outcomes. Bleeding manifestations can range from mild to severe, but the most common are mucocutaneous bleeding. The ideal treatment in RBD is dedicated single-factor concentrates that can be used for acute bleeding events, surgical management, and prophylaxis.

DOI

10.1016/j.hoc.2021.07.010

Publication Date

8-15-2021

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