Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery

Authors

Ryan C. Turner, Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA; Center for Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA.
Brandon P. Lucke-Wold, Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA; Center for Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA.
Aric F. Logsdon, Center for Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA; Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA.
Matthew J. Robson, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
John M. Lee, Department of Pathology and Laboratory Medicine, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Julian E. Bailes, Department of Neurosurgery, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Matthew L. Dashnaw, Department of Neurosurgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Jason D. Huber, Center for Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA; Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA.
Anthony L. Petraglia, Rochester Regional HealthFollow
Charles L. Rosen, Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA; Center for Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA.

Department

Neurosurgery

Document Type

Article

Publication Title

Frontiers in neurology

Abstract

Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy. Only recently have scientific laboratories and personnel begun to explore CTE pathophysiology through the use of preclinical models of neurotrauma. Some studies have shown the ability to recapitulate some aspects of CTE in rodent models, through the use of various neuropathological, biochemical, and/or behavioral assays. Many questions related to CTE development, however, remain unanswered. These include the role of impact severity, the time interval between impacts, the age at which impacts occur, and the total number of impacts sustained. Other important variables such as the location of impacts, character of impacts, and effect of environment/lifestyle and genetics also warrant further study. In this work, we attempt to address some of these questions by exploring work previously completed using single- and repetitive-injury paradigms. Despite some models producing some deficits similar to CTE symptoms, it is clear that further studies are required to understand the development of neuropathological and neurobehavioral features consistent with CTE-like features in rodents. Specifically, acute and chronic studies are needed that characterize the development of tau-based pathology.

First Page

223

DOI

10.3389/fneur.2015.00223

Volume

6

Publication Date

11-19-2015

PubMed ID

26579067

Recommended Citation

Turner, R. C., Lucke-Wold, B. P., Logsdon, A. F., Robson, M. J., Lee, J. M., Bailes, J. E., Dashnaw, M. L., Huber, J. D., Petraglia, A. L., & Rosen, C. L. (2015). Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery. Frontiers in neurology, 6, 223. https://doi.org/10.3389/fneur.2015.00223