Acute Interstitial Nephritis after Single Dose of Ketorolac

Department

Internal Medicine

Additional Department

Nephrology

Document Type

Article

Publication Title

Rhode Island Medical Journal (2013)

Abstract

Acute interstitial nephritis (AIN) is an immunologically mediated cause of acute kidney injury (AKI), most often drug-induced, with NSAIDs being a leading culprit. We present a 39-year-old woman who developed biopsy- proven AIN following a single intramuscular dose of ketorolac, an exceptionally short latency likely due to prior sensitization. Despite lacking classic systemic features, she exhibited non-oliguric AKI that improved rapidly with corticosteroids. This case underscores that NSAID-induced AIN can occur even after minimal exposure, highlighting the importance of early recognition, drug withdrawal, and timely steroid therapy to optimize renal recovery.

First Page

11

Last Page

12

Volume

109

Issue

8

Publication Date

8-1-2026

Medical Subject Headings

Humans; Female; Adult; Ketorolac; Acute Kidney Injury; Nephritis, Interstitial; Anti-Inflammatory Agents, Non-Steroidal; Kidney

PubMed ID

42520227

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