Sweet Syndrome in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge in the Setting of Chemotherapy-Induced Neutropenia
Department
Internal Medicine
Document Type
Article
Publication Title
Cureus
Abstract
A 69-year-old male with acute myeloid leukemia (AML) undergoing chemotherapy developed erythematous skin lesions at sites of prior intravenous access, along with fever and elevated inflammatory markers. Initially suspected of having resistant cellulitis or disseminated infection, his condition did not improve despite broad-spectrum antibiotics. Skin biopsy confirmed Sweet syndrome, and the patient showed rapid clinical improvement following corticosteroid therapy, with resolution of fever and skin lesions within 72 hours. This case underscores the importance of considering Sweet syndrome in neutropenic patients with unexplained fever and skin lesions, as early recognition and treatment can prevent unnecessary antibiotic use and ensure timely continuation of chemotherapy.
First Page
e110264
DOI
10.7759/cureus.110264
Volume
18
Issue
6
Publication Date
6-1-2026
PubMed ID
42403762
Recommended Citation
Abdalla, A. E., & Bajwa, J. S. (2026). Sweet Syndrome in a Patient With Acute Myeloid Leukemia: A Diagnostic Challenge in the Setting of Chemotherapy-Induced Neutropenia. Cureus, 18 (6), e110264. https://doi.org/10.7759/cureus.110264