Vascular anatomic variant-related venous thromboembolism: what a hematologist needs to know
Department
Oncology and Hematology
Document Type
Article
Publication Title
Journal of Thrombosis and Haemostasis
Abstract
This review will discuss practical aspects pertaining to deep vein thrombosis associated with 3 venous anatomical variants: duplicated femoral vein, May-Thurner syndrome, and Paget-Schroetter syndrome. Each of these conditions presents unique complexities that need to be accurately identified and managed. These conditions are very challenging for hematologists, as the first specialist to evaluate the patient is often not a hematologist but a vascular surgeon or an interventional radiologist. Key aspects from a hematologist's perspective, covering pathophysiology, clinical presentation, diagnostic approaches, and treatment strategies, are presented in concise and focused paragraphs, each followed by 3 to 4 clear, practical take-home points. Potential pitfalls and future directions are also discussed in this article.
First Page
2404
Last Page
2413
DOI
10.1016/j.jtha.2025.11.009
Volume
24
Issue
7
Publication Date
7-1-2026
Publisher
Blackwell Pub.
Medical Subject Headings
Humans; Femoral Vein; May-Thurner Syndrome; Venous Thromboembolism; Risk Factors; Anticoagulants; Predictive Value of Tests; Upper Extremity Deep Vein Thrombosis; Treatment Outcome; Hematology
PubMed ID
41352610
Recommended Citation
Kharel, H., Kharel, Z., Houghton, D. E., & Kouides, P. A. (2026). Vascular anatomic variant-related venous thromboembolism: what a hematologist needs to know. Journal of Thrombosis and Haemostasis, 24 (7), 2404-2413. https://doi.org/10.1016/j.jtha.2025.11.009