Post-myocardial infarction complications in patients with inflammatory bowel disease: a retrospective cohort study using the National Inpatient Sample (2016-2022)

Department

Internal Medicine

Document Type

Article

Publication Title

Future Cardiology

Abstract

Background: Inflammatory bowel disease (IBD) is associated with systemic inflammation and increased cardiovascular risk, but its impact on in-hospital outcomes after acute myocardial infarction (MI) remains unclear.

Methods: We conducted a retrospective cohort study using the National Inpatient Sample (2016-2022) to identify hospitalizations for acute MI and compared outcomes between patients with and without IBD. Multivariate logistic regression was used to evaluate the association between IBD and post-MI complications. Associations were summarized as adjusted odds ratios (aORs) with 95% confidence intervals (CIs).

Results: Among 1,456,940 MI hospitalizations, 7,430 had IBD. After adjustment, IBD was associated with higher odds of mortality (aOR 3.32, 95% CI 3.18-3.47; p < 0.0001), left ventricular rupture (aOR 4.46, 95% CI 3.16-6.28; p < 0.0001), left ventricular aneurysm (aOR 1.93, 95% CI 1.61-2.31; p < 0.0001), acute mitral regurgitation (aOR 9.80, 95% CI 6.81-14.10; p < 0.0001), and stent restenosis (aOR 1.16, 95% CI 1.07-1.26; p = 0.0002). IBD was also associated with longer hospital stay (coefficient 2.13 days, 95% CI 2.03-2.23; p < 0.0001) and higher total hospital charges.

Conclusion: IBD was associated with worse in-hospital outcomes and higher resource utilization after MI in this nationwide hospitalization-level analysis.

First Page

363

Last Page

371

DOI

10.1080/14796678.2026.2639403

Volume

22

Issue

4

Publication Date

4-1-2026

Medical Subject Headings

Humans; Retrospective Studies; Female; Male; Myocardial Infarction; Middle Aged; Inflammatory Bowel Diseases; United States; Hospital Mortality; Risk Factors; Inpatients; Aged; Hospitalization; Adult

PubMed ID

41772835

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