Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report
Department
Physical Medicine & Rehabilitation
Additional Department
Internal Medicine
Document Type
Article
Publication Title
Cureus
Abstract
Angiotensin-converting enzyme inhibitor-induced angioedema is a rare, potentially life-threatening disorder. This mostly manifests with swelling of the lips, tongue, and face with no known reports of angiotensin-converting enzyme inhibitor-induced angioedema from soft-tissue infections. We present herein a case of a 47-year-old male with a history of chronic kidney disease stage III who developed acute upper lip angioedema and severe acute kidney injury while on lisinopril/hydrochlorothiazide, following tattoo-related cellulitis. We propose that inflammatory activation from cellulitis amplified kallikrein-kinin system activity and bradykinin generation, precipitating angioedema in the setting of angiotensin-converting enzyme inhibition and transient renal dysfunction. This case highlights a rare but important intersection between infection-driven inflammation and angiotensin-converting enzyme inhibitor-induced angioedema.
First Page
e101391
DOI
10.7759/cureus.101391
Volume
18
Issue
1
Publication Date
1-1-2026
PubMed ID
41684981
Recommended Citation
Zedan, M., Howard, S., Foryt, P., & Aroriode, T. (2026). Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report. Cureus, 18 (1), e101391. https://doi.org/10.7759/cureus.101391