Pathophysiology of Chronic Rhinitis and Chronic Sinusitis With and Without Nasal Polyposis
Department
Allergy and Immunology
Document Type
Article
Publication Title
Immunology and Allergy Clinics of North America
Abstract
This article covers the pathophysiology of chronic rhinitis and chronic rhinosinusitis (CRS), focusing on both phenotypic and endotypic distinctions. It highlights how genetic and environmental factors contribute to disease development, emphasizing the roles of epithelial barrier dysfunction and microbiome disruption. The article categorizes CRS into forms with and without nasal polyps, each involving unique immune responses and inflammation types. Specific endotypes are also discussed, highlighting the complexity and heterogeneity of these conditions.
First Page
1
Last Page
11
DOI
10.1016/j.iac.2025.09.001
Volume
46
Issue
1
Publication Date
2-1-2026
Medical Subject Headings
Humans; Sinusitis; Nasal Polyps; Chronic Disease; Rhinitis; Microbiota
PubMed ID
41241418
Recommended Citation
Mustafa, S. S., Schmale, I., & Man, L. (2026). Pathophysiology of Chronic Rhinitis and Chronic Sinusitis With and Without Nasal Polyposis. Immunology and Allergy Clinics of North America, 46 (1), 1-11. https://doi.org/10.1016/j.iac.2025.09.001