Splanchnic Vein Thrombosis as the Initial Manifestation of Lambda Light Chain Multiple Myeloma

Department

Oncology and Hematology

Document Type

Article

Publication Title

Rhode Island Medical Journal (2013)

Abstract

We present the case of a 67-year-old man who developed superior mesenteric vein thrombosis (SMVT) as the initial manifestation of IgD lambda and lambda light chain multiple myeloma (LCMM). He initially presented with abdominal pain and was found to have SMVT without identifiable thrombophilic risk factors. Persistent macrocytosis, unexplained renal dysfunction, and mild anemia prompted further evaluation, revealing markedly elevated serum free lambda light chains, suppressed immunoglobulins, and a bone marrow biopsy confirming LCMM. This case highlights the importance of considering plasma cell dyscrasias in patients with unprovoked thrombosis at atypical sites, particularly when accompanied by subtle hematologic or renal abnormalities. Early recognition of LCMM is essential given its aggressive nature and potential for diagnostic delay due to absent or minimal findings on standard serum protein electrophoresis.

First Page

15

Last Page

17

Volume

108

Issue

10

Publication Date

10-1-2025

Medical Subject Headings

Humans; Male; Multiple Myeloma (diagnosis, complications, immunology); Aged; Immunoglobulin lambda-Chains (blood); Venous Thrombosis (etiology, diagnosis); Mesenteric Veins

PubMed ID

41002201

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