Impact of diabetes mellitus type-2 on the outcomes following mitral transcatheter edge-to-edge repair (TEER): A meta-analysis

Authors

Himaja Dutt Chigurupati, Department of Medicine, New York Medical College at Saint Michael's Medical Center, Newark, NJ, USA.
Sivaram Neppala, Department of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USA.
Rahul Chikatimalla, Department of Cardiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Ayman Fath, Department of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USA.
Prakash Upreti, Rochester Regional HealthFollow
Jeffery Bolte, Department of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USA.
Muhammad Abdullah Naveed, Department of Medicine, Dow Medical College, Karachi, Pakistan.
Adishwar Rao, Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, PA, USA.
Osama Altaee, Department of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USA.
Yasar Sattar, Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, WV, USA.
Rupak Desai, Independent Outcomes Researcher, Atlanta, GA, USA.
Ralph A. DeFronzo, Division of Diabetes, University of Texas Health Sciences Center, San Antonio, TX, USA.
Jamal S. Rana, Department of Cardiology, The Permanente Medical Group, Oakland, CA, USA.
Timir K. Paul, Department of Cardiovascular Sciences, Ascension St. Thomas Hospital/University of Tennessee Health Sciences Center, Nashville, TN, USA.

Department

Medicine

Document Type

Article

Publication Title

American Heart Journal Plus : Cardiology Research and Practice

Abstract

Background: Diabetes mellitus (DM) has been linked to unfavorable outcomes in patients undergoing Mitral Transcatheter Edge-to-Edge Repair (TEER). Nevertheless, the literature contains conflicting data. This meta-analysis aimed to assess the impact of DM on outcomes following Mitral TEER.

Methods: We searched PubMed, Scopus, and Medline for studies reporting outcomes following mitral TEER in diabetic and non-diabetic patients. Using a random-effects model, we determined the pooled odds ratio (OR) for clinical outcomes in patients who underwent Mitral TEER, regardless of their diabetes status.

Results: We included four studies with 2130 patients. DM was present in 31 % of the population, with a mean age of 73.9 (±8.2) years, 50.2 % of males, and 30 % of the population being obese. Patients with DM were more likely to be obese compared to patients without DM. In this meta-analysis, individuals with DM exhibited a higher 30-day MACCE (OR: 1.50, 95 % CI: 1.08-2.09, p = 0.02) and all-cause recurrent hospitalizations (OR: 1.36, 95 % CI: 1.07-1.72, p = 0.01) compared to those without diabetes. However, the difference in 30-day all-cause mortality (OR: 1.20, 95 % CI: 0.92-1.56, p = 0.19) and in-hospital all-cause mortality (OR: 0.92, 95 % CI: 0.51-1.67, p = 0.78) was not statistically significant between the two groups.

Conclusion: DM is associated with an increased risk of 30-day MACCE and recurrent hospitalizations following Mitral TEER. Consequently, DM should be regarded as a predictor of adverse outcomes. Future, well-designed prospective randomized trials are necessary to evaluate the mid-term impact of DM on MACCE.

First Page

100574

DOI

10.1016/j.ahjo.2025.100574

Volume

57

Publication Date

9-1-2025

PubMed ID

40703338

Recommended Citation

Chigurupati, H. D., Neppala, S., Chikatimalla, R., Fath, A., Upreti, P., Bolte, J., Naveed, M. A., Rao, A., Altaee, O., Sattar, Y., Desai, R., DeFronzo, R. A., Rana, J. S., & Paul, T. K. (2025). Impact of diabetes mellitus type-2 on the outcomes following mitral transcatheter edge-to-edge repair (TEER): A meta-analysis. American Heart Journal Plus : Cardiology Research and Practice, 57, 100574. https://doi.org/10.1016/j.ahjo.2025.100574