Allopurinol-induced Agranulocytosis: A Case Report and Review
Department
Nephrology
Document Type
Article
Publication Title
The Brown Journal of Hospital Medicine
Abstract
Allopurinol, utilized in the treatment of gouty arthritis and hyperuricemia, is one of the most prescribed medications in general medical practice. Although well-tolerated, allopurinol can cause rare and severe adverse reactions, including bone marrow toxicity. A 68-year-old man presented to the hospital with severe neutropenia and aseptic meningitis. After an extensive workup, allopurinol was determined to be the culprit medication causing severe agranulocytosis, and his blood counts recovered upon discontinuing the drug. Drug-induced agranulocytosis is a rare but serious adverse reaction. Treatment includes supportive care and discontinuation of the offending agent.
First Page
39749
DOI
10.56305/001c.39749
Volume
1
Issue
4
Publication Date
11-1-2022
PubMed ID
40046802
Recommended Citation
Reddy, A., Sekar, A., Nwankwo, N., & Kumar, A. (2022). Allopurinol-induced Agranulocytosis: A Case Report and Review. The Brown Journal of Hospital Medicine, 1 (4), 39749. https://doi.org/10.56305/001c.39749
