Chronic disseminated histoplasmosis in a patient on fingolimod therapy: A case report and review of literature
Department
Internal Medicine
Document Type
Article
Publication Title
Clinical Immunology Communications
Abstract
We present an interesting case of a 65-year-old female patient who was taking fingolimod for relapsing-remitting multiple sclerosis. She presented with a tongue nodule, oral ulcer, and was found to have CD4 lymphocytopenia. HIV serology was negative. Fingolimod is known to cause lymphocyte redistribution to lymph nodes and was deemed to be the cause of CD4 lymphocytopenia in this patient. Further evaluation with excision biopsy of the tongue nodule confirmed histoplasmosis. Treatment with itraconazole resulted in a complete resolution of her lesions.
First Page
1
Last Page
4
DOI
10.1016/j.clicom.2024.06.002
Volume
6
Publication Date
12-1-2024
Recommended Citation
Sanjeevi, A., Clark, B. L., Aguirre, A., & Verghese, B. G. (2024). Chronic disseminated histoplasmosis in a patient on fingolimod therapy: A case report and review of literature. Clinical Immunology Communications, 6, 1-4. https://doi.org/10.1016/j.clicom.2024.06.002