Efficacy and Safety of Therapeutic Hypothermia as an Adjuvant Therapy for Percutaneous Coronary Intervention in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
Department
Internal Medicine
Document Type
Article
Publication Title
Therapeutic Hypothermia and Temperature Management
Abstract
The study aims to compare the use of hypothermia in patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) with control. We systematically searched four electronic databases until March 2022. The inclusion criteria were any study design that compared hypothermia in patients with MI undergoing PCI with control. The risk of bias assessment of the included randomized controlled trials was conducted through Cochrane Tool, while the quality of the included cohort studies was assessed by the NIH tool. The meta-analysis was performed on RevMan. A total of 19 studies were entered. Regarding the mortality, there were nonsignificant differences between hypothermia and control (odds ratio [OR] = 1.06, 95% confidence interval [CI] 0.75 to 1.50, p = 0.73). There was also no significant difference between the control and hypothermia in recurrent MI (OR = 1.21, 95% CI 0.64 to 2.30, p = 0.56). On the other hand, the analysis showed a significant favor for hypothermia over the control infarct size (mean difference = -1.76, 95% CI -3.04 to -0.47, p = 0.007), but a significant favor for the control over hypothermia in the overall bleeding complications (OR = 1.88, 95% CI 1.11 to 3.18, p = 0.02). Compared with the control, hypothermia reduced the infarct size of the heart, but this finding was not consistent across studies. However, the control had lower rates of bleeding problems. The other outcomes, such as death and the incidence of recurrent MI, were similar between the two groups.
First Page
152
Last Page
171
DOI
10.1089/ther.2023.0007
Volume
14
Issue
3
Publication Date
9-1-2024
Medical Subject Headings
Humans; Hypothermia, Induced (methods, adverse effects); Percutaneous Coronary Intervention (methods, adverse effects); Myocardial Infarction (therapy, mortality); Treatment Outcome
PubMed ID
37792341
Recommended Citation
Mir, A., Rahman, M. F., Ragab, K. M., Fathallah, A. H., Daloub, S., Alwifati, N., Hagrass, A. I., Nourelden, A. Z., Elsayed, S. M., Kamal, I., Elhady, M. M., & Khan, R. (2024). Efficacy and Safety of Therapeutic Hypothermia as an Adjuvant Therapy for Percutaneous Coronary Intervention in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. Therapeutic Hypothermia and Temperature Management, 14 (3), 152-171. https://doi.org/10.1089/ther.2023.0007