Advancements in Early Detection and Screening Strategies for Pancreatic Cancer: From Genetic Susceptibility to Novel Biomarkers

Yash Shah, Department of Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, MI 48341, USA.
Dushyant Singh Dahiya, Division of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, USA.
Angad Tiwari, Department of Internal Medicine, Maharani Laxmi Bai Medical College, Jhansi 284001, Uttar Pradesh, India.
Harendra Kumar, Department of Internal Medicine, Dow University of Health Sciences, Karachi 74200, Pakistan.
Manesh Kumar Gangwani, Department of Gastroenterology and Hepatology, University of Arkansas For Medical Sciences, Little Rock, AR 72205, USA.
Hassam Ali, Division of Gastroenterology, Hepatology & Nutrition, East Carolina University/Brody School of Medicine, Greenville, NC 27834, USA.
Umar Hayat, Department of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA 18711, USA.
Saqr Alsakarneh, Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO 64110, USA.
Sahib Singh, Department of Internal Medicine, Sinai Hospital, Baltimore, MD 21215, USA.
Sheza Malik, Rochester Regional HealthFollow
Amir H. Sohail, Department of Surgery, University of New Mexico, Albuquerque, NM 87131, USA.
Saurabh Chandan, Center for Interventional Endoscopy (CIE), Advent Health, Orlando, FL 32803, USA.
Meer A. Ali, Department of Gastroenterology and Hepatology, University of Arkansas For Medical Sciences, Little Rock, AR 72205, USA.
Sumant Inamdar, Department of Gastroenterology and Hepatology, University of Arkansas For Medical Sciences, Little Rock, AR 72205, USA.

Department

Internal Medicine

Document Type

Article

Publication Title

Journal of Clinical Medicine

Abstract

Pancreatic cancer is a rare but lethal cancer due to its biologically aggressive nature, advanced stage at the time of diagnosis, and poor response to oncologic therapies. The risk of pancreatic cancer is significantly higher to 5% in certain high-risk individuals with inherited genetic susceptibility. Screening for pancreatic cancer in these individuals from high-risk groups can help with the early detection of pancreatic cancer as well as the detection of precursor lesions leading to early surgical resection and improved overall outcomes. The advancements in radiological imaging as well as advanced endoscopic procedures has made a significant impact on the early diagnosis, surveillance, and staging of pancreatic cancer. There is also a significant advancement in the development of biomarkers for the early detection of pancreatic cancer, which has also led to the development of liquid biopsy, allowing for microRNA detection in serum and circulating tumor cells. Various societies and organizations have provided guidelines for pancreatic cancer screening and surveillance in high-risk individuals. In this review, we aim to discuss the hereditary risk factors for developing pancreatic cancer, summarize the screening recommendations by different societies, and discuss the development of novel biomarkers and areas for future research in pancreatic cancer screening for high-risk individuals.

First Page

4706

DOI

10.3390/jcm13164706

Volume

13

Issue

16

Publication Date

8-10-2024

PubMed ID

39200847

Link to Full Text

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