Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes

Hesham Elsabah, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Rola Ghasoub, Department of Pharmacy, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Dina S. Soliman, Department of Laboratory Medicine and Pathology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Feryal Ibrahim, Department of Laboratory Medicine and Pathology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Mahmood B. Aldapt, Rochester Regional HealthFollow
Ruba Y. Taha, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Safaa Al Azawi, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Deena Mudawi, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Abbas Moustafa, Department of Radiology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Halima Elomri, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Honar Cherif, Division of Hematology, Department of Medical Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.

Department

Internal Medicine

Document Type

Article

Publication Title

Cancer Reports (Hoboken, N.J.)

Abstract

BACKGROUND: Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple myeloma (MM). In this study, we report the clinical and radiological characteristics, management, and outcomes of patients under the age of 40 who presented with skull base plasmacytoma and associated neurological manifestations. Additionally, we share our experience in treating a rare case of skull base plasmacytoma diagnosed during pregnancy, in which the patient exhibited a favorable response to myeloma treatment initiated after delivery.

CASE SERIES: Four patients were identified, comprising one pregnant female and three male patients, with a median age of 36 years (range 33-37 years). The main presenting symptoms were headache, dizziness, and cranial nerve palsy. All patients received underwent systemic myeloma therapy and radiotherapy with three patients also underwent autologous stem cell transplantation (ASCT). Notably, all patients achieved complete remission.

CONCLUSION: Skull base plasmacytoma represents a rare manifestation of plasma cell neoplasms, underscoring the importance of considering it in the differential diagnosis of skull base lesions to ensure early intervention and avoid potential serious complications. Throughout our series, the cornerstone of therapy involved radiotherapy, systemic myeloma therapy, and ASCT, all of which elicited a favorable response in every case.

First Page

e2106

DOI

10.1002/cnr2.2106

Volume

7

Issue

7

Publication Date

7-1-2024

Medical Subject Headings

Humans; Male; Plasmacytoma (therapy, pathology, diagnosis); Adult; Female; Skull Base Neoplasms (pathology, therapy); Pregnancy; Multiple Myeloma (therapy, pathology, diagnosis); Transplantation, Autologous; Treatment Outcome; Pregnancy Complications, Neoplastic (pathology, therapy, diagnosis); Magnetic Resonance Imaging

PubMed ID

38967112

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