Outcomes of Impella compared with intra-aortic balloon pump in ST-elevation myocardial infarction complicated by cardiogenic shock.
Department
Internal Medicine
Additional Department
Cardiology
Document Type
Article
Publication Title
American Heart Journal Plus : Cardiology Research and Practice
Abstract
Background: Despite limited randomized trial data demonstrating clinical efficacy, the utilization of Impella in ST-elevation myocardial infarction (STEMI) patients complicated with cardiogenic shock (CS) has increased over time.
Methods: We identified 75,769 hospitalizations with STEMI complicated by CS between October 2015 and December 2018 using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes. From this cohort, hospitalizations were stratified according to IABP or Impella placement. The primary outcome was all-cause in-hospital mortality. Secondary outcomes were divided into efficacy, safety, and device-related complications. Propensity-score matching was used to account for differences in the baseline characteristics between the groups. Logistic regression was performed to get the odds ratio and confidence intervals.
Results: Among 75,769 admissions with STEMI and CS, hospitalizations with < 18 years old, both IABP and Impella placement, and who underwent ECMO and/or LVAD implantation were excluded. After the exclusion, out of 72,791 admissions, 25,260 (34.70%) hospitalizations received IABP, and 7825 (10.75%) received Impella support. After propensity score-matched analysis, 7345 hospitalizations were included in each group. All-cause in-hospital mortality was higher in the hospitalizations requiring Impella support as compared to IABP (42.10% vs. 31.54%, adjusted OR 1.71; 95% confidence interval (CI) 1.60-1.84, P < 0.0001). Impella was associated with a higher risk of in-hospital complications and hospitalization cost compared with IABP.
Conclusion: Impella compared with IABP in STEMI patients with CS was associated with higher in-hospital mortality and other adverse clinical and procedural outcomes.
First Page
100067
DOI
10.1016/j.ahjo.2021.100067
Volume
12
Publication Date
12-1-2021
PubMed ID
38559603
Recommended Citation
Thakkar, S., Patel, H. P., Kumar, A., Tan, B. E., Arora, S., Patel, S., Doshi, R., Depta, J. P., Kalra, A., Dani, S., Deshmukh, A., Badheka, A., Widmer, R., Mamas, M., Rihal, C., Girotra, S., & Panaich, S. (2021). Outcomes of Impella compared with intra-aortic balloon pump in ST-elevation myocardial infarction complicated by cardiogenic shock.. American Heart Journal Plus : Cardiology Research and Practice, 12, 100067. https://doi.org/10.1016/j.ahjo.2021.100067