Fatal Itching and Failing Liver: A Case Report and Literature Review of Rare, Atypical DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome

Authors

Mohammed Abusuliman, Internal Medicine, Henry Ford Health System, Detroit, USA.
Mahmoud Amreia, Rochester Regional HealthFollow
Sheema Rehman, Internal Medicine, Henry Ford Health System, Detroit, USA.
Ammad J. Chaudhary, Internal Medicine, Henry Ford Health System, Detroit, USA.
Hazem Abosheaishaa, Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York City, USA.
Taher Jamali, Gastroenterology, Henry Ford Health System, Detroit, USA.
Amir Hanafi, Rochester Regional HealthFollow

Department

Internal Medicine

Document Type

Article

Publication Title

Cureus

Abstract

DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome is a rare, life-threatening, hypersensitivity reaction. The prolonged course and non-specific symptoms of the condition make diagnosis challenging. We present a case of DRESS syndrome that was misdiagnosed as urticaria. Investigations revealed deranged liver and kidney functions and abnormal blood count. The presented case emphasizes the need to have a high suspicion for DRESS syndrome in patients who present with jaundice, generalized rash, acute renal failure, and acute liver failure.

First Page

e55355

DOI

10.7759/cureus.55355

Volume

16

Issue

3

Publication Date

3-1-2024

PubMed ID

38559511

Recommended Citation

Abusuliman, M., Amreia, M., Rehman, S., Chaudhary, A. J., Abosheaishaa, H., Jamali, T., & Hanafi, A. (2024). Fatal Itching and Failing Liver: A Case Report and Literature Review of Rare, Atypical DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome. Cureus, 16 (3), e55355. https://doi.org/10.7759/cureus.55355