Safety and Efficacy of Cangrelor in Acute Coronary Syndromes: A Systematic Review and Network Meta-Analysis

Department

Internal Medicine

Additional Department

Cardiology

Document Type

Article

Publication Title

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions

Abstract

Introduction: Cangrelor is a potent intravenous non-thienopyridine P2Y12 inhibitor. We conducted a network meta-analysis to study the efficacy and safety of cangrelor as compared with the oral P2Y12 inhibition, clopidogrel, or placebo in acute coronary syndromes.

Methods: This meta-analysis followed the Cochrane collaboration guidelines and the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocols. Outcomes of interest included all-cause mortality, myocardial infarction, stent thrombosis, target vessel revascularization, major bleeding, minor bleeding, and the need for blood transfusion.

Results: The analysis was comprised of 6 studies including 26,444 patients treated with cangrelor, clopidogrel, or placebo. There were no statistically significant differences in the incidence of all-cause mortality, myocardial infarction, stent thrombosis, target vessel revascularization, or major bleeding. Cangrelor was associated with a higher risk of minor bleeding than clopidogrel or placebo, with no difference in requiring blood transfusion.

Conclusion: Cangrelor has comparable outcomes to clopidogrel in patients with acute coronary syndromes and can be used as a reliable alternative in this population.

First Page

71

Last Page

81

DOI

10.1007/s40256-023-00616-2

Volume

24

Issue

1

Publication Date

1-1-2024

Medical Subject Headings

Humans; Clopidogrel (therapeutic use); Acute Coronary Syndrome (therapy); Platelet Aggregation Inhibitors (adverse effects); Network Meta-Analysis; Purinergic P2Y Receptor Antagonists (adverse effects); Adenosine Monophosphate (adverse effects); Myocardial Infarction (drug therapy); Hemorrhage (chemically induced, epidemiology, drug therapy); Percutaneous Coronary Intervention (adverse effects, methods); Treatment Outcome; Thrombosis (drug therapy)

PubMed ID

37995040

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