Very early life microbiome and metabolome correlates with primary vaccination variability in children
Department
Research
Document Type
Article
Publication Title
mSystems
Abstract
We show that simultaneous study of stool and nasopharyngeal microbiome reveals divergent timing and patterns of maturation, suggesting that local mucosal factors may influence microbiome composition in the gut and respiratory system. Antibiotic exposure in early life as occurs commonly, may have an adverse effect on vaccine responsiveness. Abundance of gut and/or nasopharyngeal bacteria with the machinery to produce lipopolysaccharide-a toll-like receptor 4 agonist-may positively affect future vaccine protection, potentially by acting as a natural adjuvant. The increased levels of serum phenylpyruvic acid in infants with lower vaccine-induced antibody levels suggest an increased abundance of hydrogen peroxide, leading to more oxidative stress in low vaccine-responding infants.
First Page
e0066123
DOI
10.1128/msystems.00661-23
Volume
8
Issue
5
Publication Date
10-26-2023
Medical Subject Headings
Infant; Child; Humans; Gastrointestinal Microbiome; Microbiota; Metabolome; Vaccines; Vaccination
PubMed ID
37610205
Recommended Citation
Shaffer, M., Best, K., Tang, C., Liang, X., Schulz, S., Gonzalez, E., White, C. H., Wyche, T. P., Kang, J., Wesseling, H., Topçuoğlu, B. D., Cairns, T., Sana, T. R., Kaufhold, R. M., Maritz, J. M., Woelk, C. H., Swaminathan, G., Norton, J. E., & Pichichero, M. E. (2023). Very early life microbiome and metabolome correlates with primary vaccination variability in children. mSystems, 8 (5), e0066123. https://doi.org/10.1128/msystems.00661-23