Very early life microbiome and metabolome correlates with primary vaccination variability in children

Authors

Michael Shaffer, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Katharine Best, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Catherine Tang, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Xue Liang, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Steven Schulz, Rochester Regional HealthFollow
Eduardo Gonzalez, Rochester Regional HealthFollow
Cory H. White, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Thomas P. Wyche, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
John Kang, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Hendrik Wesseling, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Begüm D. Topçuoğlu, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Thomas Cairns, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Theodore R. Sana, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Robin M. Kaufhold, Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc. , West Point, Pennsylvania, USA.
Julia M. Maritz, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Christopher H. Woelk, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Gokul Swaminathan, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
James E. Norton, Exploratory Science Center, Merck & Co., Inc. , Cambridge, Massachusetts, USA.
Michael E. Pichichero, Rochester Regional HealthFollow

Department

Research

Document Type

Article

Publication Title

mSystems

Abstract

We show that simultaneous study of stool and nasopharyngeal microbiome reveals divergent timing and patterns of maturation, suggesting that local mucosal factors may influence microbiome composition in the gut and respiratory system. Antibiotic exposure in early life as occurs commonly, may have an adverse effect on vaccine responsiveness. Abundance of gut and/or nasopharyngeal bacteria with the machinery to produce lipopolysaccharide-a toll-like receptor 4 agonist-may positively affect future vaccine protection, potentially by acting as a natural adjuvant. The increased levels of serum phenylpyruvic acid in infants with lower vaccine-induced antibody levels suggest an increased abundance of hydrogen peroxide, leading to more oxidative stress in low vaccine-responding infants.

First Page

e0066123

DOI

10.1128/msystems.00661-23

Volume

8

Issue

5

Publication Date

10-26-2023

Medical Subject Headings

Infant; Child; Humans; Gastrointestinal Microbiome; Microbiota; Metabolome; Vaccines; Vaccination

PubMed ID

37610205

Share

COinS