Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin for Atrial Fibrillation in End-Stage Renal Disease on Hemodialysis: A Meta-Analysis of Randomized Control Trials
Department
Internal Medicine
Document Type
Article
Publication Title
The American Journal of Cardiology
Abstract
End-stage renal disease (ESRD) and atrial fibrillation (AF) are commonly encountered, with ESRD itself serving as a well-established risk factor for AF.1 The 2018 AF guidelines have recommended apixaban across all the spectrums of renal impairment, including patients on hemodialysis (HD), and the 2019 American Heart Association/American College of Cardiology/Heart Rhythm Society updated guidelines have suggested careful consideration of reduced dose of direct oral anticoagulants (DOACs) in patients with ESRD.2,3 The current data on the safety and efficacy of warfarin versus DOACs in patients with AF with ESRD and HD is variable. This study aimed to perform a study-level meta-analysis to evaluate the effectiveness and safety of warfarin and DOACs in patients with AF who require dialysis.
First Page
309
Last Page
311
DOI
10.1016/j.amjcard.2023.08.116
Volume
206
Publication Date
11-1-2023
PubMed ID
37722229
Recommended Citation
Faisaluddin, M., Alwifati, N., Naeem, N., Balasubramanian, S., Narasimhan, B., Iqbal, U., & Dani, S. S. (2023). Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin for Atrial Fibrillation in End-Stage Renal Disease on Hemodialysis: A Meta-Analysis of Randomized Control Trials. The American Journal of Cardiology, 206, 309-311. https://doi.org/10.1016/j.amjcard.2023.08.116