Emerging from the shadows: A rare case of gastrointestinal AL amyloidosis presenting as hematemesis

Authors

Ali Jaan, Rochester Regional HealthFollow
Zouina Sarfraz, Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan.
Joel McFarland, Rochester Regional HealthFollow
Patrick I. Okolo, Rochester Regional HealthFollow
Karin Dunnigan, Rochester Regional HealthFollow
Jason Gutman, Rochester Regional HealthFollow

Department

Internal Medicine

Document Type

Article

Publication Title

Proceedings (Baylor University. Medical Center)

Abstract

We document a unique presentation of light chain (AL) amyloidosis in a 62-year-old man exhibiting as acute hematemesis and chronic abdominal discomfort. Esophagogastroduodenoscopy disclosed marked thickening of gastric and duodenal folds, gastroduodenal nodularity, and friable ulcerations. Biopsy confirmed amyloidosis. Subsequent investigations ratified a diagnosis of systemic AL amyloidosis with cardiac involvement. Initiation of the cyclophosphamide, bortezomib, and dexamethasone (CyBorD) regimen, along with tafamidis and doxycycline for cardiac pathology, led to substantial improvement of abdominal symptoms. This case highlights the variability in amyloidosis presentations and the importance of early diagnosis.

First Page

758

Last Page

760

DOI

10.1080/08998280.2023.2257113

Volume

36

Issue

6

Publication Date

9-2023

PubMed ID

37829217

Recommended Citation

Jaan, A., Sarfraz, Z., McFarland, J., Okolo, P. I., Dunnigan, K., & Gutman, J. (2023). Emerging from the shadows: A rare case of gastrointestinal AL amyloidosis presenting as hematemesis. Proceedings (Baylor University. Medical Center), 36 (6), 758-760. https://doi.org/10.1080/08998280.2023.2257113