Direct challenges are the gold standard for most antibiotic allergy evaluations
Department
Allergy and Immunology
Document Type
Article
Publication Title
Annals of Allergy, Asthma & Immunology
Abstract
Antibiotic allergies are frequently encountered in clinical practice, and delabeling of these allergies has individual and public health benefits. This review focuses on the evidence supporting graded challenges without preceding skin testing in adult and pediatric patients to the major groups of antibiotics including penicillins, cephalosporins, sulfamethoxazole, fluoroquinolones, tetracyclines, macrolides, metronidazole, carbapenems, and aztreonam. The cost savings, time savings, and evidence for performing graded challenges outside of an allergy/immunology office are also reviewed for graded challenges to penicillins.
First Page
427
Last Page
433
DOI
10.1016/j.anai.2023.03.033
Volume
131
Issue
4
Publication Date
10-1-2023
Publisher
American College of Allergy, Asthma, and Immunology
PubMed ID
37031773
Recommended Citation
Ramsey, A., Rozario, C., & Stern, J. (2023). Direct challenges are the gold standard for most antibiotic allergy evaluations. Annals of Allergy, Asthma & Immunology, 131 (4), 427-433. https://doi.org/10.1016/j.anai.2023.03.033