Worsening Hypothyroidism in the Setting of New-Onset Nephrotic Syndrome

Authors

Qi Wang, Rochester Regional HealthFollow
Divya Ravi, Rochester Regional HealthFollow
Zhiting Tang, Rochester Regional HealthFollow
Nikita Nand, Rochester Regional HealthFollow
Ala Dahhan, Rochester Regional HealthFollow

Department

Internal Medicine

Document Type

Article

Publication Title

Cureus

Abstract

We present a case of a 54-year-old female with well-controlled hypothyroidism who experienced worsening symptoms due to nephrotic syndrome. The patient presented with fatigue, progressive shortness of breath on exertion, and anasarca for one month. Laboratory results revealed significantly elevated thyroid-stimulating hormone levels and nephrotic range proteinuria. A kidney biopsy showed stage I membranous nephropathy with positive phospholipase A2 receptor (PLA2R) findings. Her symptoms gradually improved after receiving a higher dose of levothyroxine, along with diuretics and lisinopril initiation. She continued to be closely monitored by both endocrinology and nephrology outpatient services. This case report highlights the importance of closely monitoring hypothyroidism treatment when significant proteinuria is present.

First Page

e43345

DOI

10.7759/cureus.43345

Volume

15

Issue

8

Publication Date

8-1-2023

PubMed ID

37701005

Recommended Citation

Wang, Q., Ravi, D., Tang, Z., Nand, N., & Dahhan, A. (2023). Worsening Hypothyroidism in the Setting of New-Onset Nephrotic Syndrome. Cureus, 15 (8), e43345. https://doi.org/10.7759/cureus.43345