Acquired elliptocytosis in chronic myeloid neoplasms: An enigmatic relationship to acquired red cell membrane protein and genetic abnormalities
Department
Oncology and Hematology
Document Type
Article
Publication Title
Blood Cells, Molecules & Diseases
Abstract
Nineteen reports of 41 cases of acquired red cell elliptocytosis associated with a chronic myeloid neoplasm are described. Although the majority of cases have an abnormality of the long arm of chromosome 20, del(q20), several cases do not. Moreover, in one case a specific qualitative abnormality of red cell protein band 4.1(4.1R) was reported; however, several subsequent cases could find no abnormality of a red cell membrane protein or found a different abnormality, usually quantitative. Thus, this striking red cell phenotypic feature, acquired elliptocytosis, seen in myelodysplastic syndrome and other chronic myeloproliferative diseases, closely simulating the red cell phenotype of hereditary elliptocytosis, has an unexplained genetic basis, presumably as the result of an acquired mutation(s) in some chronic myeloid neoplasms.
First Page
102778
DOI
10.1016/j.bcmd.2023.102778
Volume
103
Publication Date
11-1-2023
Publisher
Academic Press
Medical Subject Headings
Humans; Elliptocytosis, Hereditary; Membrane Proteins; Neoplasms; Erythrocytes; Erythrocyte Membrane; Myeloproliferative Disorders; Cytoskeletal Proteins
PubMed ID
37379758
Recommended Citation
Lichtman, M. A., & Sham, R. (2023). Acquired elliptocytosis in chronic myeloid neoplasms: An enigmatic relationship to acquired red cell membrane protein and genetic abnormalities. Blood Cells, Molecules & Diseases, 103, 102778. https://doi.org/10.1016/j.bcmd.2023.102778