Per rectal endoscopic myotomy for Hirschsprung's disease and megacolon

Authors

Ashish Gandhi, Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Maharashtra, India.
Jay Bapaye, Rochester Regional HealthFollow
Amol Bapaye, Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Maharashtra, India

Department

Internal Medicine

Document Type

Article

Publication Title

Minerva Gastroenterology

Abstract

Hirschsprung's disease (HD) is a congenital disorder characterized by absence of intrinsic ganglion cells of the hindgut. It commonly presents in infancy with refractory constipation and failure to thrive. Short segment HD affecting the rectosigmoid region is the commonest variant. Although surgical or laparoscopic single or multi-stage pull-through procedures have been the gold standard for more than six decades, these procedures are associated with significant morbidity, recurrence, and often multi-stage procedures. Per-rectal endoscopic myotomy (PREM) is a recently described novel minimally invasive procedure based on the principles of third space endoscopy. It is based on the principle to open spastic aganglionic bowel segments by performing a myotomy through a submucosal tunnel. This review describes the patient selection and preparation and technique of PREM and discusses the status of PREM for treatment of HD.

First Page

175

Last Page

183

DOI

10.23736/S2724-5985.22.03166-7

Volume

69

Issue

2

Publication Date

6-1-2023

PubMed ID

35343667

Recommended Citation

Gandhi, A., Bapaye, J., & Bapaye, A. (2023). Per rectal endoscopic myotomy for Hirschsprung's disease and megacolon. Minerva Gastroenterology, 69 (2), 175-183. https://doi.org/10.23736/S2724-5985.22.03166-7