Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis

Authors

Angelica Ezeigwe, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Oluseye Ogunmoroti, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Anum S. Minhas, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Carla P. Rodriguez, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Brigitte Kazzi, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Oluwaseun E. Fashanu, Rochester Regional HealthFollow
Olatokunbo Osibogun, Department of Epidemiology, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, United States.
Lara C. Kovell, Division of Cardiology, University of Massachusetts Chan School of Medicine, Worchester, MA, United States.
Colleen M. Harrington, Corrigan's Women's Heart Health Program, Massachusetts General Hospital, Boston, MA, United States.
Erin D. Michos, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Department

Cardiology

Document Type

Article

Publication Title

Frontiers in Cardiovascular Medicine

Abstract

Introduction: Multiparity has been associated with increased risk of cardiovascular disease (CVD). Inflammation may be a mechanism linking parity to CVD. We investigated the association between parity and later-life markers of inflammation.

Methods: We studied 3,454 female MESA participants aged 45-84, free of CVD, who had data on parity and inflammatory markers. Parity was categorized as 0 (reference), 1-2, 3-4, or ≥ 5. Linear regression was used to evaluate the association between parity and natural log-transformed levels of fibrinogen, D-dimer, GlycA, high sensitivity C-reactive protein (hsCRP), and interleukin-6 (IL-6).

Results: Mean age was 62 ± 10 years. The proportion of women with nulliparity, 1-2, 3-4, and ≥ 5 live births were 18, 39, 29, and 14%, respectively. There was no association between parity and fibrinogen. Women with grand multiparity (≥ 5 live births) had 28, 10, and 18% higher levels of hsCRP, IL-6 and D-dimer, respectively, compared to nulliparous women, after adjustment for demographic factors. After additional adjustment for CVD risk factors, women with 1-2 and 3-4 live births had higher hsCRP and women with 1-2 live births had higher GlycA.

Conclusion: In this diverse cohort of middle-to-older aged women, we found that higher parity was associated with some inflammatory markers; however, these associations were largely attenuated after adjustment for CVD risk factors. There was no clear dose-response relationship between parity and these inflammatory markers. Future studies are needed to evaluate how inflammation may influence the link between parity and CVD and whether healthy lifestyle/pharmacotherapies targeting inflammation can reduce CVD risk among multiparous women.

Clinical trial registration: The MESA cohort design is registered at clinicaltrials.gov as follows: https://clinicaltrials.gov/ct2/show/NCT00005487.

First Page

922367

DOI

10.3389/fcvm.2022.922367

Volume

9

Publication Date

9-14-2022

PubMed ID

36186982

Recommended Citation

Ezeigwe, A., Ogunmoroti, O., Minhas, A. S., Rodriguez, C. P., Kazzi, B., Fashanu, O. E., Osibogun, O., Kovell, L. C., Harrington, C. M., & Michos, E. D. (2022). Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis. Frontiers in Cardiovascular Medicine, 9, 922367. https://doi.org/10.3389/fcvm.2022.922367