Racial disparities in ventricular tachycardia in young adults: analysis of national trends

Authors

Harsh P. Patel, Department of Cardiology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Samarthkumar Thakkar, Department of Cardiovascular Medicine, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Nishaki Mehta, Department of Cardiovascular Medicine, Oakland University William Beaumont School of Medicine, Beaumont Hospital Royal Oak, Royal Oak, MI, USA.
Mohammed Faisaluddin, Rochester Regional HealthFollow
Rezwan F. Munshi, Department of Medicine, Nassau University Medical Center, East Meadow, NY, USA.
Ashish Kumar, Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, USA.
Safi U. Khan, Department of Cardiovascular Medicine, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Rohan Parikh, Department of Cardiology, Lahey Hospital & Medical Center, 41 Burlington Mall Road, Burlington, MA, 01805, USA.
Christopher V. DeSimone, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Garima Sharma, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abhishek Deshmukh, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Khurram Nasir, Department of Cardiovascular Medicine, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Sarju Ganatra, Department of Cardiology, Lahey Hospital & Medical Center, 41 Burlington Mall Road, Burlington, MA, 01805, USA.
Sourbha S. Dani, Department of Cardiology, Lahey Hospital & Medical Center, 41 Burlington Mall Road, Burlington, MA, 01805, USA.

Department

Internal Medicine

Document Type

Article

Publication Title

Journal of Interventional Cardiac Electrophysiology

Abstract

BACKGROUND: In the last two decades, risk factors, prevalence, and mortality due to coronary artery disease in young adults are on the rise. We sought to assess the prevalence, trends, and economic burden of ventricular tachycardia (VT) hospitalizations in young adults (< 45 years), further stratified by race and gender.

METHODS: The Nationwide Inpatient Sample was explored for hospitalizations with VT in patients (< 45 years) between 2005 and 2018 and divided among 3 groups of the quadrennial period using validated International Classification of Diseases (ICD) 9 and 10 revision Clinical Modification (CM) codes. The Pearson chi-square test and Wilcoxon rank-sum were used for categorical and continuous variables, respectively. We assessed the temporal trends of mortality in VT hospitalizations and trends of VT hospitalization stratified by age, sex, and race by using Joinpoint regression analysis. The primary outcome was in-hospital mortality trends. Secondary outcomes were trends of hospital stay in days, cost of care in US dollars, cardiac arrest, and discharge disposition.

RESULTS: Out of 5,156,326 patients admitted with VT between 2005 and 2018, 309,636 were young adults. Among them, 102,433 were admitted between 2005 and 2009 (mean age 36.1 ± 6.99; 61% male, 58.5% White), 109,591 between 2010 and 2014 (mean age 35.5 ± 7.16; 59% male, 54.2% White), and 97,495 between 2015 and 2018 (mean age 35.4 ± 7.00; 60% male, 52.3% White) (p < 0.07). In the young adults with VT, all-cause mortality was 7.37% from 2005 to 2009, 7.85% from 2010 to 2014 (6.5% relative increase from 2005 to 2009), and 8.98% from 2015 to 2018 (relative increase of 14.4% from 2010 to 2014) (p < 0.0001). Similarly, risk of cardiac arrest was on the rise (6.15% from 2005 to 2009 to 7.77% in 2010-2014 and 9.97% in 2015-2018). Inflation-adjusted cost increased over the years [$12,177 in 2005-2009; $13,249 in 2010-2014; $15,807 in 2015-2018; p < 0.0001)].

CONCLUSIONS: VT hospitalizations and related all-cause mortality, and healthcare utilization costs in young adults are on the rise in the study period. Hospitalization burden related to VT and poor outcomes were more notable for Black adults. Further studies are required for targeted screening and preventative measures in young adults.

First Page

193

Last Page

202

DOI

10.1007/s10840-022-01335-5

Volume

66

Issue

1

Publication Date

1-2023

Comments

Record updated with published article citation 2023-02-20 LB.

Published online ahead of print 2022-08-10.

PubMed ID

35947319

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