Prevalence of Pseudomonas aeruginosa in Diabetic Foot Infections in the United States: A Systematic Review and Meta-analysis

Department

Podiatry

Document Type

Article

Publication Title

Foot & Ankle Surgery: Techniques, Reports & Cases

Abstract

Pseudomonas aeruginosa is an uncommon cause of diabetic foot infections. However, it is one of the most common gram negative bacteria found in diabetic wounds. The aim of this systematic review and meta-analysis is to determine the prevalence of Pseudomonas aeruginosa in diabetic foot infections in the United States.

PubMed was searched from inception to September, 2020. Only studies that obtained samples from populations within the United States and also reported the number of patient's positive for Pseudomonas aeruginosa were included. The primary meta-analysis outcome was prevalence of Pseudomonas aeruginosa in diabetic foot infections in the United States. The meta-analysis was carried out using MetaXL software.

Ten studies, conducted between 1990 and 2020, met the inclusion criteria and contributed 9513 diabetic patients (sample size range, 34-5403). The pooled estimation of prevalence of Pseudomonas aeruginosa in diabetic foot infections in the United States was 8.06% (95% CI, 6.18–10.16%).. Prevalence in the included studies varied from 4.46% to 14.71%. We found a high heterogeneity (I2= 85%, p < 0.000, Q = 61.37) in prevalence reported among studies.

This meta-analysis demonstrates that there is a low prevalence of Pseudomonas aeruginosa in diabetic foot infections in the United States. This study should encourage providers to avoid initiating anti-Pseudomonas therapies frequently in patient with diabetic foot infections when they lack generally recognized risk factors.

DOI

10.1016/j.fastrc.2022.100189

Publication Date

3-8-2022

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