Amyloidosis Is Associated with Increased Risk of Atrial Fibrillation. A Forgotten Link between Uncommon and Common Cardiac Conditions. Analysis from the National Inpatient Sample

Department

Cardiology

Document Type

Conference Proceeding

Publication Title

Circulation

Conference Name

American Heart Association's 2021 Scientific Sessions

Conference Date

2021-01-01

Abstract

Objective: This study aims at identifying the relationship between amyloidosis and atrial fibrillation Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and mortality. Recent advances in cardiac imaging have increased the frequency of diagnosis of cardiac amyloidosis. Data is limited on the role of cardiac amyloid in patients with AF. Methods: This is a retrospective cohort study of patients with amyloidosis from the National Inpatient Sample (NIS) 2014. The primary outcome was diagnosis of AF in the amyloidosis vs. non-amyloidosis population. Logistic regression models were used to assess predictors of AF among the study population. Results: 5, 872,587 health encounters from the NIS were identified. Of these, 4,287 subjects had a diagnosis of amyloidosis. AF was found in 28.7% of the amyloidosis vs. 13.4% % of the non-amyloidosis group, p < 0.001. The average age of the amyloidosis is 71 yrs. old, female represents 55.9% of the study population. Systolic heart failure (8.5% vs. 3.9%, p < 0.001), diastolic heart failure (14.7% vs. 4.6%, p < 0.001), ischemic stroke (6.3% vs. 1.9%, p < 0.001) and chronic kidney disease (42.3% vs. 14.4%, p < 0.001) were more prevalent in the amyloidosis vs. non-amyloidosis group. Amyloidosis was associated with the black ethnicity (19.4% vs. 14.1%, p < 0.001). In addition, diabetes mellitus, hypertension, and obesity were common in the amyloidosis group. On multivariate analysis, amyloidosis was a strong predictor of AF (OR 1.37 (95% CI 1.28-1.47, p < 0.001)) Conclusion: AF and amyloidosis are mutually associated identities. High suspicion should be maintained for the diagnosis of amyloidosis in patients presenting with AF. This may allow early recognition and treatment of underlying amyloidosis in patients with AF.

Volume

144

Issue

Suppl_1

Publication Date

11-8-2021

Comments

Session Title: QCOR At Sessions: Quality of care and outcomes Research II; Abstract 12843

Link to Full Text

Share

COinS