The relationship of myometrial histopathology (metropathy) to myometrial dysfunction and clinical manifestations
Department
Pathology
Document Type
Article
Publication Title
Annals of Diagnostic Pathology
Abstract
Myometrial morphology and myometrial physiology have been considered to be separate entities; however, observations of myometrial morphology and associated dysfunctions suggest a relationship between myometrial morphology and myometrial physiology that deserves further exploration. Although myometrial electrical activity can be monitored by electrohysterogram, the association of increased myometrial contractions with an increase in electrical activity (due to an increase in gap junctions) is typically not evaluated. Although the association of increased myometrial contractions with increase in pain can be monitored by tocometry and intrauterine pressure catheters, respectively, this is generally not done in the non-pregnant uteri. Although standard morphologic evaluations routinely include evaluation with special stains and immunohistochemistry in other organ systems, such as skeletal and cardiac muscle, these evaluations are not standard or routine for myometrium in hysterectomies. The purpose of this review is to discuss non-neoplastic myometrial histology, with consideration of the potential value of using tools to measure variations in myometrial physiology, in order to reliably correlate myometrial histology with myometrial function (and dysfunction).
First Page
151902
DOI
10.1016/j.anndiagpath.2022.151902
Volume
57
Publication Date
2-1-2022
PubMed ID
35123151
Recommended Citation
Turner, B. M., Cramer, S. F., & Heller, D. S. (2022). The relationship of myometrial histopathology (metropathy) to myometrial dysfunction and clinical manifestations. Annals of Diagnostic Pathology, 57, 151902. https://doi.org/10.1016/j.anndiagpath.2022.151902