Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants
Department
Research
Document Type
Article
Publication Title
The Journal of Infectious Diseases
Abstract
BACKGROUND: We sought to understand why some children respond poorly to vaccinations in the first year of life. METHODS: A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed with enzyme-linked immunosorbent assay, and frequency of memory B cells, functional T-cell responses, and antigen-presenting cell responses were assessed in peripheral blood mononuclear cell samples with flow cytometric analysis. RESULTS: Eleven percent of children were low vaccine responders, defined a priori as those with subprotective immunoglobulin G antibody levels to ≥66% of vaccines tested. Low vaccine responders generated fewer memory B cells, had reduced activation by CD4(+) and CD8(+) T cells on polyclonal stimulation, and displayed lower major histocompatibility complex II expression by antigen-presenting cells. CONCLUSIONS: We conclude that subprotective vaccine responses in infants are associated with a distinct immunologic profile.
First Page
2014
Last Page
9
DOI
10.1093/infdis/jiw053
Volume
213
Issue
12
Publication Date
6-15-2016
Medical Subject Headings
Antibodies (blood); Antigen-Presenting Cells (immunology); B-Lymphocytes (immunology); CD8-Positive T-Lymphocytes (immunology); Child, Preschool; Cytokines (immunology); Diphtheria Toxoid (administration & dosage, immunology); Enzyme-Linked Immunosorbent Assay; Humans; Immunization, Secondary; Immunologic Memory; Infant; Leukocytes, Mononuclear (immunology); Male; Pertussis Vaccine (administration & dosage, immunology); Polysaccharides (administration & dosage, immunology); Tetanus Toxoid (administration & dosage, immunology); Vaccines (administration & dosage, immunology); Vaccines, Acellular (administration & dosage, immunology); Vaccines, Conjugate (administration & dosage, immunology)
PubMed ID
26908730
Recommended Citation
Pichichero, M. E., Casey, J. R., Almudevar, A., Basha, S., Surendran, N., Kaur, R., Morris, M., Livingstone, A. M., & Mosmann, T. R. (2016). Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants. The Journal of Infectious Diseases, 213 (12), 2014-9. https://doi.org/10.1093/infdis/jiw053
