Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae

Department

Research

Document Type

Article

Publication Title

Expert Review of Vaccines

Abstract

Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, protein D and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.

First Page

863

Last Page

78

DOI

10.1586/14760584.2016.1156539

Volume

15

Issue

7

Publication Date

7-1-2016

Medical Subject Headings

Antigens, Bacterial (immunology); Drug Discovery (trends); Haemophilus Infections (prevention & control); Haemophilus Vaccines (immunology, isolation & purification); Haemophilus influenzae (immunology); Humans; Otitis Media (prevention & control); Vaccines, Subunit (immunology, isolation & purification)

PubMed ID

26894630

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