Infants with low vaccine antibody responses have altered innate cytokine response

Department

Research

Document Type

Article

Publication Title

Vaccine

Abstract

We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.

First Page

5700

Last Page

5703

DOI

10.1016/j.vaccine.2016.09.050

Volume

34

Issue

47

Publication Date

11-11-2016

Medical Subject Headings

Adaptive Immunity; Antibody Formation (immunology); Cells, Cultured; Chemokine CCL5 (blood); Humans; Imidazoles (pharmacology); Immunity, Innate; Infant; Interferon-alpha (blood, drug effects); Interleukin-12 (antagonists & inhibitors, blood); Interleukin-1beta (blood, drug effects); Leukocytes, Mononuclear (drug effects, immunology); Longitudinal Studies; Prospective Studies; Statistics, Nonparametric; Toll-Like Receptor 7 (antagonists & inhibitors); Toll-Like Receptor 8 (antagonists & inhibitors); Vaccination; Vaccines (administration & dosage, immunology)

PubMed ID

27745950

Link to Full Text

Share

COinS