Aspirin Use Prior to Coronary Artery Bypass Grafting Surgery: a Systematic Review

Department

Medicine

Document Type

Article

Publication Title

Current Cardiology Reports

Abstract

PURPOSE OF REVIEW: Aspirin use before coronary artery bypass graft (CABG) surgery has been a puzzling question for years. Controversy existed regarding the overall benefits vs. risk of pre-operative aspirin use and was translated to conflicting guidelines from major societies. RECENT FINDINGS: Observational studies have suggested a reduced mortality with pre-operative aspirin use. A meta-analysis of randomized controlled trials showed increased risk of post-operative bleeding with aspirin, with no associated increased mortality risk. A recent large randomized controlled trial did not find a significant difference in bleeding risk or post-operative mortality with pre-CABG aspirin use. The results of available studies showed a beneficial effect with pre-CABG aspirin use by decreasing thrombotic complications and perioperative myocardial infarction, with an associated adverse risk of bleeding that did not affect mortality rates. Given overall benefit-risk assessment, we are in favor of pre-operative aspirin use in CABG patients.

First Page

18

DOI

10.1007/s11886-017-0822-5

Volume

19

Issue

2

Publication Date

2-1-2017

Medical Subject Headings

Aspirin (adverse effects, therapeutic use); Coronary Artery Bypass; Coronary Artery Disease (therapy); Humans; Meta-Analysis as Topic; Myocardial Infarction (chemically induced); Platelet Aggregation Inhibitors (adverse effects, therapeutic use); Postoperative Hemorrhage (chemically induced); Practice Guidelines as Topic; Preoperative Care; Randomized Controlled Trials as Topic; Risk Assessment

PubMed ID

28213669

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