Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

Department

Research

Document Type

Article

Publication Title

Expert Review of Vaccines

Abstract

Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Areas covered: Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections. Expert commentary: A long-term strategy for prevention of pneumococcal disease will likely include WCV and PPVs. However these vaccines will impact disease pathogenesis in a different manner than PCVs. Prevention of pneumococcal NP colonization should not be expected, nor is it desirable because risks for NP colonization by other replacement organisms into the ecological niche vacated by all pneumococci may have consequences. The expression biology of capsule and surface protein antigens are phase dependent. Therefore, the immune response will be different and the mechanism of protection divergent. WCVs and PPVs may be alternative strategies in low income developing countries to protect against invasive disease and reduce NP carriage load.

First Page

1181

Last Page

1190

DOI

10.1080/14760584.2017.1393335

Volume

16

Issue

12

Publication Date

12-1-2017

Medical Subject Headings

Drug Discovery (trends); Humans; Pneumococcal Infections (prevention & control); Pneumococcal Vaccines (immunology); Streptococcus pneumoniae (immunology); Vaccines, Inactivated (immunology); Vaccines, Subunit (immunology)

PubMed ID

29130395

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