Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness

Editor

Yan Q.

Department

Research

Document Type

Book Chapter

Publication Title

Psychoneuroimmunology. Methods in Molecular Biology

Abstract

Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response to a challenge. We demonstrate the practical application of such an approach using an example where blood was collected from 26 GWI, 13 healthy control subjects, and 9 unhealthy controls with chronic fatigue at three points during a graded exercise challenge. A 3-way multivariate projection model based on 12 markers of endocrine and immune function was constructed using a training set of n = 10 GWI and n = 11 healthy controls. These groups were separated almost completely on the basis of two co-expression patterns. In a separate test set these same features allowed for discrimination of new GWI subjects (n = 16) from unhealthy (n = 9) and healthy control subjects with a sensitivity of 70% and a specificity of 90%.

First Page

101

Last Page

120

DOI

10.1007/978-1-4939-7828-1_7

Volume

1781

Publication Date

1-1-2018

Publisher

Humana Press, New York, NY

Medical Subject Headings

Adult; Biomarkers (blood); Case-Control Studies; Cohort Studies; Cytokines (blood); Exercise Test; Female; Gulf War; Humans; Male; Middle Aged; Models, Theoretical; Persian Gulf Syndrome (blood, diagnosis, immunology)

PubMed ID

29705845

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