Accidental Daily Dosing: Severe Methotrexate Toxicity in a Patient with Rheumatoid Arthritis

Authors

Sidra Memon, Piedmont Macon Medical CenterFollow
Kavitha Vemuri, Piedmont Macon Medical CenterFollow
Syed Uzair Mahmood, University of Texas Health Science Center at HoustonFollow
Darshit Patel, Piedmont Macon Medical CenterFollow

Author Credentials

Sidra Memon, MD

Kavitha Vemuri, MD

Syed Uzair Mahmood, MD, MPH, MBA

Darshit Patel, MD

Abstract

This case highlights a crucial complication of oral methotrexate therapy: toxicity due to dosing errors. A patient’s daily dosing regimen, instead of the intended weekly schedule, led to a significantly excessive cumulative dose of methotrexate over a short period, resulting in severe hematologic and mucosal toxicity. This underscores the importance of clear patient education and vigilant prescription practices to prevent such errors.

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Recommended Citation

Memon S, Vemuri K, Mahmood S, Patel D. Accidental Daily Dosing: Severe Methotrexate Toxicity in a Patient with Rheumatoid Arthritis. Advances in Clinical Medical Research and Healthcare Delivery. 2025; 5(4):70-73. doi: 10.53785/2769-2779.1331.