Could Sigmoid Diverticulitis, Drug-Induced Liver Injury, and Drug-Induced Pancreatitis Co-occur?

Authors

Rutwik Pradeep Sharma, Department of Medicine, RRH/Unity HospitalFollow
Ryan Tam, Medical Student year 3, Lake Erie College of Osteopathic Medicine (LECOM)Follow
Michael Labuzetta, Department of Medicine, RRH/Unity HospitalFollow
Richard Alweis, Rochester RegionalFollow

Author Credentials

1st author- Rutwik P Sharma

PGY3 IM resident

2nd author- Ryan Tam

3rd year Medical student at LEICOM

3rd author- Micheal Labuzetta

Hospitalist at Unity Hospital

4th author- Richard Alweis

Internal Medicine attending, Unity faculty partners

Author ORCID Identifier

0000-0003-3788-7496

Abstract

Sigmoid diverticulitis is a leading cause of gastrointestinal pathology etiology, which causes hospital admissions in Western society. Recent studies have shown its prevalence to be 1-4%. Drug-induced liver injury (DILI) is a primary cause of acute liver failure in the West^. The incidence of DILI is between 14-19 cases per 100,000 population. The prevalence of drug-induced pancreatitis (DIP) is 2-5%, although this is hard to estimate given the lack of large-scale studies. Sulfasalazine is a disease-modifying antirheumatic drug that is indicated for the treatment of chronic inflammatory diseases such as rheumatoid arthritis and ulcerative colitis. It has been associated with severe adverse reactions such as pancreatitis or liver injury. We present a patient with a triad of DILI, DIP, and sigmoid diverticulitis in the setting of the recent initiation of sulfasalazine. Such a clinical scenario has not been previously reported in medical literature.

Creative Commons License

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Recommended Citation

Sharma R, Tam R, Labuzetta M, Alweis R. Could Sigmoid Diverticulitis, Drug-Induced Liver Injury, and Drug-Induced Pancreatitis Co-occur?. Advances in Clinical Medical Research and Healthcare Delivery. 2024; 4(4). doi: 10.53785/2769-2779.1264.