Non-respiratory manifestations of COVID-19, including dermatological manifestations, have been reported, and although urticaria associated with COVID-19 has been reported, there have been no reports of non-histaminergic angioedema following infection with mild COVID-19. Non-histaminergic angioedema has a gradual onset and is characterized by submucosal swelling without accompanying urticaria or pruritus, and poor response to antihistamines and corticosteroids. We report a case of non-histaminergic angioedema in a 29-year-old woman with a history of mild COVID-19 infection. Our case highlights the fact that early diagnosis of non-histaminergic angioedema in mild COVID-19 patients is crucial for effective treatment and requires a high level of suspicion from both general and emergency physicians.
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Malik S, Verghese B, Mustafa S. Non-Histaminergic Angioedema Following Infection with COVID-19. Advances in Clinical Medical Research and Healthcare Delivery. 2023; 3(3). doi: 10.53785/2769-2779.1168.