Author Credentials

Dylan Thibaut: Biomedical Sciences BS; Science Education BS. Minor: World Languages Education- Teaching English for Speakers of Other Languages

Connor Sweeney: Biology BS

Shannon South: Biology BS. Minor: Psychology

Mohamed Hussein: M.S., Ph.D.: Medical Physiology


Background: Human leukocyte antigen (HLA) class II has shown potential in determining prognosis, understanding medication reactions, and predicting onset of Graves’ disease. The aim of this study is to further investigate the association between Graves’ disease and HLA class II, specifically HLA-DQ and HLA-DR, via meta-analysis to find HLAs that can be further examined for prognostic reasons.

Methods: Statistical analysis was performed to determine if variants of HLA-DQA1, HLA-DQB1, or HLA-DRB1 were associated with significantly altered odds of Graves’ disease. A minimum of three studies pertaining to a particular HLA was required for inclusion. Studies were excluded if they lacked inclusion criteria.

Results: 27 studies were included. Odds of associated HLAs in Graves’ disease patients versus controls were increased for HLA-DQA1*03:01 (OR = 1.30 [1.03, 1.63], I² =0%, p

Discussion: These findings offer new connections between HLAs and Graves’ disease that may be applied to prognosis, treatment, and autoimmune mechanistic understanding for MHC class II in Graves’ disease.

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License